农业细菌毒力质粒具有出乎意料的保守性和全球

添加时间:2020-06-08 浏览数:

本期文章:《科学》:Volume 368 Issue 6495

美国俄勒冈州立大学Jeff H. Chang研究组的最新发现表明,农杆菌毒力质粒具有出乎意料的保守性和全球性传播。相关论文发表在2020年6月2日出版的《科学》杂志上。

研究人员制定了表征毒力质粒的策略,并将其用于分析1927年至2017年之间在六大洲和50多个宿主物种中收集的数百种菌株。研究人员惊奇地发现,致癌质粒是从几个保守的谱系衍生而来的。特征层次结构的表征推断出整个质粒谱系的进化历史。

 

研究人员揭示了其中的流行病学模式,并表明了质粒传播在病原体多样化、长期持续存在以及全球传播中的重要性。

 

据悉,病原体的加速进化和传播是对宿主物种的威胁。农杆菌需要致癌的Ti或Ri质粒才能将基因转移到植物中并引起疾病。

 

附:英文原文

Title: Unexpected conservation and global transmission of agrobacterial virulence plasmids

Author: Alexandra J. Weisberg, Edward W. Davis, Javier Tabima, Michael S. Belcher, Marilyn Miller, Chih-Horng Kuo, Joyce E. Loper, Niklaus J. Grünwald, Melodie L. Putnam, Jeff H. Chang

Issue&Volume: 2020/06/05

Abstract: The accelerated evolution and spread of pathogens are threats to host species. Agrobacteria require an oncogenic Ti or Ri plasmid to transfer genes into plants and cause disease. We developed a strategy to characterize virulence plasmids and applied it to analyze hundreds of strains collected between 1927 and 2017, on six continents and from more than 50 host species. In consideration of prior evidence for prolific recombination, it was surprising that oncogenic plasmids are descended from a few conserved lineages. Characterization of a hierarchy of features that promote or constrain plasticity allowed inference of the evolutionary history across the plasmid lineages. We uncovered epidemiological patterns that highlight the importance of plasmid transmission in pathogen diversification as well as in long-term persistence and the global spread of disease.

DOI: 10.1126/science.aba5256

Source: https://science.sciencemag.org/content/368/6495/eaba5256

期刊信息

Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037

官方网址:https://www.sciencemag.org/